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Exophthalmos, also known as proptosis, is a medical term for a bulging or protruding eyeball or eyeballs. It's most often caused by thyroid eye disease.
Many of the symptoms of thyroid eye disease tend to improve over time, although this can take a number of years. There's a chance your eyes will continue to protrude if corrective surgery isn't carried out.
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See your GP or an optometrist (optician) if you notice that one or both of your eyes are protruding.
It's important to identify the underlying cause so appropriate treatment can be given. Treatment is often more effective if it's started as soon as possible.
If necessary, your GP or optometrist can refer you to an ophthalmologist (a specialist in diagnosing and treating eye conditions) for further assessment.
If you're referred to an ophthalmologist, they'll check how well you're able to move your eyes. They may also use an instrument called an exophthalmometer to measure how far your eyeball protrudes.
You may also have a blood test to assess how well your thyroid gland is working and you may be referred to an endocrinologist (a specialist in conditions affecting glands and hormones) if you're found to have abnormal thyroid hormone levels.
One of the main causes of exophthalmos in the UK is thyroid eye disease, also known as Graves' ophthalmopathy.
This is an autoimmune condition that affects around one in every three people with an overactive thyroid gland (hyperthyroidism) caused by Graves' disease. It's particularly common in women aged 30-50 and people who smoke.
An autoimmune condition is where the immune system (the body's defence against illness and infection) mistakenly attacks healthy tissue.
In the case of thyroid eye disease, the immune system attacks the muscles and fatty tissues around and behind the eye, causing them to become inflamed (swollen).
Thyroid eye disease can also occasionally affect people with an underactive thyroid gland (hypothyroidism) and, in rare cases, people with seemingly normal thyroid function.
Exophthalmos can also have a number of other causes, but these are generally less common than thyroid eye disease.
Other causes of exophthalmos can include:
Exophthalmos can also affect newborn babies if they're born with eye sockets that are shallower than normal.
If exophthalmos is being caused by thyroid eye disease, the following treatments are often helpful:
Other useful measures include stopping smoking, using artificial tears to reduce eye dryness and irritation, and wearing special lenses to correct double vision.
In other cases, treatment will vary depending on the underlying cause. For example, treatments such as radiotherapy, chemotherapy and/or surgery may be recommended if exophthalmos is caused by a tumour.
Read more about treating exophthalmos.
Depending on what's causing your bulging eyes, you may also have other associated symptoms. For example, if exophthalmos is caused by a thyroid eye disease, your eyes may also be:
You may also experience some double vision.
In severe cases of exophthalmos, you may not be able to close your eyes properly. This can damage your corneas (the transparent tissue that covers the front of your eye) by causing them to dry out.
If your corneas become very dry, an infection or ulcers (open sores) may develop. These could damage your vision if left untreated.
There's also a small risk of the optic nerve (which transmits signals from the eye to the brain) becoming compressed if you have exophthalmos, which may affect your sight permanently if it isn't treated quickly.
Treatment for exophthalmos (bulging eyes) largely depends on what is causing the problem.
In some cases, an ophthalmologist (eye specialist) may feel immediate treatment isn't necessary. You may only be advised to have regular examinations to monitor your condition.
If you have thyroid eye disease, your treatment may involve several different stages. This is because the condition tends to progress through two main phases:
Typically, the initial active phase lasts for between several months and around two years.
Some of the main treatments you may be offered if you have thyroid eye disease are described below.
If you have an overactive thyroid gland (hyperthyroidism) or an underactive thyroid gland (hypothyroidism), you'll usually be offered medication to help correct the level of thyroid hormones in your blood.
For example, an overactive thyroid can be treated with medication such as thionamides, which prevent your thyroid gland producing excess amounts of thyroid hormones.
Treating your thyroid problems will not necessarily improve your eye-related symptoms, but it may help prevent other problems associated with abnormal thyroid levels. It may also help the problems affecting your eyes from getting worse.
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You may also be advised about things you can do, and treatments that are available, to relieve some of the symptoms associated with the active phase of thyroid eye disease.
If your thyroid eye disease is mild, these measures – along with the medications to correct your thyroid hormone levels mentioned above – may be all the treatment you need.
In more severe cases, when the eyes are particularly painful and inflamed during the active stage of thyroid eye disease, corticosteroids may be recommended by your doctor.
Corticosteroids are powerful medications that can help bring the inflammation associated with thyroid eye disease under control. They can help ensure the condition is stable before any type of surgery (see below) is considered.
In many cases, corticosteroids given directly into a vein (intravenously) are recommended. This is because taking corticosteroid tablets over a long period of time can have significant side effects.
A typical course of treatment with intravenous corticosteroids involves weekly treatments over a 10-12 week period. You should start to notice an improvement in your condition after a week or two.
Severe side effects of intravenous corticosteroids are uncommon, but you may experience some short-lived problems for a few days following the treatment sessions, such as:
Read more about the side effects of corticosteroids.
Occasionally, orbital or retrobulbar radiotherapy may be considered during the active stage of thyroid eye disease if corticosteroids haven't been effective. It may also be combined with corticosteroids.
This treatment uses high-energy radiation, usually X-rays, to destroy cells. Low doses of radiation can be used on the tissues and muscles in the eye socket to help reduce the swelling.
During treatment, you'll lie down and a special shell will be placed over your head to keep it still. A machine is used to carefully direct beams of radiation at the area being treated.
This is usually done on an outpatient basis, which means you won't need to stay in hospital overnight. Treatment typically involves around 10 sessions over a two-week period.
Radiotherapy can cause some side effects, although these should be minimal as the treatment will be confined to a specific area and shouldn't affect other parts of your body. However, possible side effects may include:
In some cases, surgery may be considered as a treatment for exophthalmos if you have severe or persistent symptoms.
For example, surgery may be considered to improve the appearance of the eyes if exophthalmos has been in the inactive phase for a few months. Medical treatment alone won't necessarily reverse the protrusion of the eyes.
Surgery may also be carried out during the active phase of thyroid eye disease if there's an immediate threat to your vision due to compression of the optic nerve (which transmits signals from the eye to the brain).
Surgery may also be effective if the exophthalmos is caused by other problems, such as issues with the blood vessels behind the eyes.
There are three main types of surgery that may be carried out on people with exophthalmos, although it's unusual for someone to have all three. These are:
These procedures are usually carried out under general anaesthetic, which means you'll be asleep. Depending on the type and extent of the operation you have, you may need to stay in hospital for up to a few days afterwards.
Orbital decompression surgery is most often carried out to improve the appearance of the eyes of people with thyroid eye disease who are affected by exophthalmos. It may also be required to reduce any pressure on the optic nerve.
During the procedure, a small amount of bone is removed from your eye sockets (orbits) and some of the fat surrounding the socket may also be removed.
This allows any excess tissue that's pushing the eyeballs forward to move down into the space below. It also allows your eyes to sit further back in your head, so they don't protrude forward as much.
This procedure is carried out under general anaesthetic and normally involves making incisions near where your eyelids meet in the inner corner of your eyes (the point nearest the nose). You may need to stay in hospital for a day or two after this procedure, so your recovery can be closely monitored.
Possible complications that can occur following orbital decompression surgery include:
If you're considering having orbital decompression surgery, ask your doctor or surgeon to explain the benefits and risks of the procedure to you.
For most other problems that cause exophthalmos, treatment will vary, depending on the underlying cause.
For example, if you have an infection affecting the tissue in your eye socket, such as cellulitis, your ophthalmologist may prescribe antibiotics to treat the infection. They may also need to carry out a procedure to drain any abscesses that have developed.
If you have a tumour behind your eye, your doctors will discuss treatment options with you. For most types of cancer, treatment involves one or more of the following: